Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart.

@article{Doyle2006Latrophilin2IA,
  title={Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart.},
  author={Sally E Doyle and Matthew J Scholz and Kevin A. Greer and Antony D Hubbard and Diana K. Darnell and Parker B. Antin and Scott E. Klewer and Raymond B Runyan},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2006},
  volume={235 12},
  pages={3213-21}
}
Endothelial cells in the atrioventricular canal of the heart undergo an epithelial-mesenchymal transition (EMT) to form heart valves. We surveyed an on-line database (http://www.geisha.arizona.edu/) for clones expressed during gastrulation to identify novel EMT components. One gene, latrophilin-2, was identified as expressed in the heart and appeared to be functional in EMT. This molecule was chosen for further examination. In situ localization showed it to be expressed in both the myocardium… CONTINUE READING

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