Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives.

@article{Jiao2015LathyrolDA,
  title={Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives.},
  author={Wei Jiao and Zhongmin Wan and Shuang Xiu Chen and Runhua Lu and Xiaozhen Chen and Dongmei Fang and Jiufeng Wang and Shengcai Pu and Xin Huang and Haixiang Gao and Huawu Shao},
  journal={Journal of medicinal chemistry},
  year={2015},
  volume={58 9},
  pages={3720-38}
}
Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp). Eight derivatives exhibited greater chemoreversal ability than verapamil (VRP) against adriamycin (ADR) resistance… CONTINUE READING