Lathyrism: A Review

@article{Barrow1974LathyrismAR,
  title={Lathyrism: A Review},
  author={Mark V. Jr. Barrow and Charles F. Simpson and E J Miller},
  journal={The Quarterly Review of Biology},
  year={1974},
  volume={49},
  pages={101 - 128}
}
Lathyrism encompases two entities. The first, neurolathyrism, occurs in a variety of animals, including man, after the consumption of several Lathyrus species. Three distinct neurolathyrogens have been isolated thus far from these plants. Clinical manifestations are marked by spastic paraplegia, and degenerative pathological changes are noted in the spinal cord to account for this effect. The other type of lathryrism, observed mainly in rats and turkeys, and not in man, is called osteolathyrism… 
Historical setting and neuropathology of lathyrism: Insights from the neglected 1944 report by Oliveras de la Riva
TLDR
A landmark but little-known Spanish-language neuropathological study of two patients with lathyrism of recent onset, where Oliveras de la Riva proposed that the segmental spinal pathology arose because distal regions of elongate pyramidal tract axons are distant from their trophic center in the motor cortex, a view not far from the current distal axonopathy concept of lATHyrism.
Lathyrus hirsutus (Caley Pea) Intoxication in a Herd of Horses
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The neurologic signs of horses intoxicated with Caley Pea suggest involvement of the upper motor neuron system and regions of the spinal cord influencing voluntary motor movement and Drought conditions during plant growth may increase the risk of toxicosis.
Lathyrus and Lathyrism: A review
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The authors have reviewed and documented the lethal manifestation of seeds of Lathyrus sp.
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This review focuses on a specific cause of lameness known as bacterial chondronecrosis with osteomyelitis (BCO) in broilers, and demonstrates that BCO incidences can be reduced by prophylactically providing probiotics in the feed, by therapeutically adding 25-hydroxy vitamin D3 to the drinking water, or by therapeutic adding the antibiotic enrofloxacin to the water.
Altered collagene characteristics and lysyl oxidase activity in lathyrism
TLDR
It has been detected essential structural changes in extracellular matrix based on the collagen cross-links reduction and semicarbazide influences not only the enzymic development of aldehyde groups in collagen, but the level of other aldehydes, which can cause cross- links.
Thiosemicarbazide-induced osteolathyrism in metamorphosing Xenopus laevis.
Exposure of Xenopus laevis tadpoles to thiosemicarbazide (TSC), at concentrations from 10 to 75 mg/liter, causes an inhibition of metamorphosis and produces the classic manifestations of the
Somatometric characteristic of hypermobile patients with coxarthrosis
TLDR
The study summarizes results of somatometric measurements in 38 hypermobile women with coxarthrosis based on congenital dislocation of the hip and the same number of hypermobile controls to recommend use in the primary preventive care of coXarthrosis.
Myxomatous degeneration and cystic medial necrosis associated with acromegaly.
TLDR
A patient with mitral insufficiency, acromegaly documented by growth hormone levels, myxomatous degeneration of all four cardiac valves, and cystic medial necrosis of the aorta and pulmonary artery is observed, presenting further evidence that excess growth hormone may potentiate the connective tissue cardiovascular lesions in acromEGaly.
Structure-activity relationships for osteolathyrism: I. Effects of altering the semicarbazide structure.
TLDR
Although semicarbazide had no effect on the developing liver, it did induce skeletal abnormalities similar to those described by Chang et al. (1954), in an effort to produce liver damage in chick embryos similar to that observed following administration of aminoguanidine.
Cysteamine toxicity in patients with cystinosis.
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