Lathyrism: A Review

  title={Lathyrism: A Review},
  author={Mark V. Jr. Barrow and Charles F. Simpson and E J Miller},
  journal={The Quarterly Review of Biology},
  pages={101 - 128}
Lathyrism encompases two entities. The first, neurolathyrism, occurs in a variety of animals, including man, after the consumption of several Lathyrus species. Three distinct neurolathyrogens have been isolated thus far from these plants. Clinical manifestations are marked by spastic paraplegia, and degenerative pathological changes are noted in the spinal cord to account for this effect. The other type of lathryrism, observed mainly in rats and turkeys, and not in man, is called osteolathyrism… 
Historical setting and neuropathology of lathyrism: Insights from the neglected 1944 report by Oliveras de la Riva
A landmark but little-known Spanish-language neuropathological study of two patients with lathyrism of recent onset, where Oliveras de la Riva proposed that the segmental spinal pathology arose because distal regions of elongate pyramidal tract axons are distant from their trophic center in the motor cortex, a view not far from the current distal axonopathy concept of lATHyrism.
Lathyrus hirsutus (Caley Pea) Intoxication in a Herd of Horses
The neurologic signs of horses intoxicated with Caley Pea suggest involvement of the upper motor neuron system and regions of the spinal cord influencing voluntary motor movement and Drought conditions during plant growth may increase the risk of toxicosis.
Lathyrus and Lathyrism: A review
The authors have reviewed and documented the lethal manifestation of seeds of Lathyrus sp.
Bacterial chondronecrosis with osteomyelitis and lameness in broilers: a review.
This review focuses on a specific cause of lameness known as bacterial chondronecrosis with osteomyelitis (BCO) in broilers, and demonstrates that BCO incidences can be reduced by prophylactically providing probiotics in the feed, by therapeutically adding 25-hydroxy vitamin D3 to the drinking water, or by therapeutic adding the antibiotic enrofloxacin to the water.
Altered collagene characteristics and lysyl oxidase activity in lathyrism
It has been detected essential structural changes in extracellular matrix based on the collagen cross-links reduction and semicarbazide influences not only the enzymic development of aldehyde groups in collagen, but the level of other aldehydes, which can cause cross- links.
Thiosemicarbazide-induced osteolathyrism in metamorphosing Xenopus laevis.
Exposure of Xenopus laevis tadpoles to thiosemicarbazide (TSC), at concentrations from 10 to 75 mg/liter, causes an inhibition of metamorphosis and produces the classic manifestations of the
Somatometric characteristic of hypermobile patients with coxarthrosis
The study summarizes results of somatometric measurements in 38 hypermobile women with coxarthrosis based on congenital dislocation of the hip and the same number of hypermobile controls to recommend use in the primary preventive care of coXarthrosis.
Myxomatous degeneration and cystic medial necrosis associated with acromegaly.
A patient with mitral insufficiency, acromegaly documented by growth hormone levels, myxomatous degeneration of all four cardiac valves, and cystic medial necrosis of the aorta and pulmonary artery is observed, presenting further evidence that excess growth hormone may potentiate the connective tissue cardiovascular lesions in acromEGaly.
Structure-activity relationships for osteolathyrism: I. Effects of altering the semicarbazide structure.
Although semicarbazide had no effect on the developing liver, it did induce skeletal abnormalities similar to those described by Chang et al. (1954), in an effort to produce liver damage in chick embryos similar to that observed following administration of aminoguanidine.
Cysteamine toxicity in patients with cystinosis.


Scoliosis and dissecting aneurysm of the aorta in rats fed with Lathyrus odoratus seeds.
It has been found that the protein metabolism is at fault in these children with idiopathic scoliosis and the lesions produced by the pea meal are not due solely to a protein deficiency.
Biochemistry of experimental lathyrism.
Lesions of the skeleton and of other mesodermal tissues in rats fed sweet-pea (Lathyrus odoratus) seeds.
  • I. Ponseti
  • Medicine, Biology
    The Journal of bone and joint surgery. American volume
  • 1954
Two lesions developed concomitantly,—degeneration of the joint cartilage and loosening of the capsular and ligamentous insertions and it is surmised that all these lesions are due to defective formation or excessive destruction of the chondroitin sulphate of the ground substance.
Studies on the Production of Aortic Hemorrhage in Growing Turkeys with Beta-aminopropionitrile
Following its chemical isolation and the demonstration that beta-aminopropionitrile (BAPN) produced odoratism in rats, Barnett, Bird, Lalich and Strong demonstrated that BAPN produced a syndrome in turkey poults characterized by hock and toe deformity, pericardial hemorrhage, aortic rupture, and growth depression.
Preliminary investigation of the relationship between bovine congenital lathyrism induced by aminoacetonitrile and the lupine induced crooked calf disease.
Maternal feeding of the lathyrogen aminoacetonitrile, the range plant Lupinus caudatus, and an extract of this plant - expected to contain lathyrogens if present in the plant - all produced clinically similar congenital defects in calves, suggesting a possible relationship between lathyrism and lupine-induced crooked calf disease.
Osteolathyrogenic effects on the developing rat foetus.
  • V. Ferm
  • Biology
    Journal of embryology and experimental morphology
  • 1960
The present study was devised to determine the effect of a known osteolathyrogenic agent during specific stages of gestation and especially to observe theeffect of this agent during the early critical stages of embryogenesis.
An apparent relationship between locoism and lathyrism.
It was demonstrated that the known lathyrogens, aminoacetonitrile and alpha, gamma-diaminobutyric acid, as well as an extract from the loco plant (expected to contain lathyrogen if present in the plant) produced many of the abortive, teratogenic and neurologic effects and signs evident in animals in true locoism.
Pathology of the Nervous System
Lathyrus Factor Activity of Beta-Aminopropionitrile and Related Compounds.∗
Summary β-amino propionitrile will produce all the changes which have been described in rats fed 50% Lathyrus odoratus pea meal. None of the supplements fed with BAPN inhibited the development of