Lathyrism: A Review

@article{Barrow1974LathyrismAR,
  title={Lathyrism: A Review},
  author={Mark V. Jr. Barrow and Charles F. Simpson and E J Miller},
  journal={The Quarterly Review of Biology},
  year={1974},
  volume={49},
  pages={101 - 128}
}
Lathyrism encompases two entities. The first, neurolathyrism, occurs in a variety of animals, including man, after the consumption of several Lathyrus species. Three distinct neurolathyrogens have been isolated thus far from these plants. Clinical manifestations are marked by spastic paraplegia, and degenerative pathological changes are noted in the spinal cord to account for this effect. The other type of lathryrism, observed mainly in rats and turkeys, and not in man, is called osteolathyrism… Expand
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Historical setting and neuropathology of lathyrism: Insights from the neglected 1944 report by Oliveras de la Riva
TLDR
A landmark but little-known Spanish-language neuropathological study of two patients with lathyrism of recent onset, where Oliveras de la Riva proposed that the segmental spinal pathology arose because distal regions of elongate pyramidal tract axons are distant from their trophic center in the motor cortex, a view not far from the current distal axonopathy concept of lATHyrism. Expand
Lathyrus hirsutus (Caley Pea) Intoxication in a Herd of Horses
TLDR
The neurologic signs of horses intoxicated with Caley Pea suggest involvement of the upper motor neuron system and regions of the spinal cord influencing voluntary motor movement and Drought conditions during plant growth may increase the risk of toxicosis. Expand
Lathyrus and Lathyrism: A review
TLDR
The authors have reviewed and documented the lethal manifestation of seeds of Lathyrus sp. Expand
Bacterial chondronecrosis with osteomyelitis and lameness in broilers: a review.
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This review focuses on a specific cause of lameness known as bacterial chondronecrosis with osteomyelitis (BCO) in broilers, and demonstrates that BCO incidences can be reduced by prophylactically providing probiotics in the feed, by therapeutically adding 25-hydroxy vitamin D3 to the drinking water, or by therapeutic adding the antibiotic enrofloxacin to the water. Expand
Altered collagene characteristics and lysyl oxidase activity in lathyrism
: Experiments were carried out on rats with lathyrism, which was induced by adding semicarbazide (0.075%) into drinking water for 45 days. The data obtained show a 30% reduction in the body weight… Expand
Thiosemicarbazide-induced osteolathyrism in metamorphosing Xenopus laevis.
Exposure of Xenopus laevis tadpoles to thiosemicarbazide (TSC), at concentrations from 10 to 75 mg/liter, causes an inhibition of metamorphosis and produces the classic manifestations of the… Expand
Somatometric characteristic of hypermobile patients with coxarthrosis
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The study summarizes results of somatometric measurements in 38 hypermobile women with coxarthrosis based on congenital dislocation of the hip and the same number of hypermobile controls to recommend use in the primary preventive care of coXarthrosis. Expand
Myxomatous degeneration and cystic medial necrosis associated with acromegaly.
TLDR
A patient with mitral insufficiency, acromegaly documented by growth hormone levels, myxomatous degeneration of all four cardiac valves, and cystic medial necrosis of the aorta and pulmonary artery is observed, presenting further evidence that excess growth hormone may potentiate the connective tissue cardiovascular lesions in acromEGaly. Expand
Structure-activity relationships for osteolathyrism: I. Effects of altering the semicarbazide structure.
TLDR
Although semicarbazide had no effect on the developing liver, it did induce skeletal abnormalities similar to those described by Chang et al. (1954), in an effort to produce liver damage in chick embryos similar to that observed following administration of aminoguanidine. Expand
Cysteamine toxicity in patients with cystinosis.
TLDR
Cysteamine administration can be complicated by the development of skin, vascular, neurologic, muscular, and bone lesions that improve after cysteamine dose reduction, and underdosing should be prescribed with great caution. Expand
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References

SHOWING 1-10 OF 152 REFERENCES
Biochemistry of experimental lathyrism.
  • E. Kulonen
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1961
TLDR
Experimental lathyrism showed that the alkali-soluble hydroxyproline was increased five-fold; but good analytical data were not obtainable on the constituents of alkali -soluble collagen. Expand
Isolation and identification from common vetch of the neurotoxin beta-cyano-L-alanine, a possible factor in neurolathyrism.
  • C. Ressler
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1962
TLDR
The experimental condition produced with either the odoratus factor or with a number of synthetic compounds related to P-aminopropionitrile has resulted chiefly in abnormalities of bone and mesenchymal tissue in contradistinction to human lathyrism which is neurologic in character. Expand
Lathyrism in Mice
TLDR
Experiments were continued with the aim of confirming Dasler and Milliser's work and producing lathyrism in a cheap and easily handled animal or, if the mouse were resistant, of using this difference in response between two such closely related species as the rat and the mouse for investigation of the pathogenesis of lATHyrism. Expand
Lesions of the skeleton and of other mesodermal tissues in rats fed sweet-pea (Lathyrus odoratus) seeds.
  • I. Ponseti
  • Medicine
  • The Journal of bone and joint surgery. American volume
  • 1954
TLDR
Two lesions developed concomitantly,—degeneration of the joint cartilage and loosening of the capsular and ligamentous insertions and it is surmised that all these lesions are due to defective formation or excessive destruction of the chondroitin sulphate of the ground substance. Expand
Studies on the Production of Aortic Hemorrhage in Growing Turkeys with Beta-aminopropionitrile
TLDR
Following its chemical isolation and the demonstration that beta-aminopropionitrile (BAPN) produced odoratism in rats, Barnett, Bird, Lalich and Strong demonstrated that BAPN produced a syndrome in turkey poults characterized by hock and toe deformity, pericardial hemorrhage, aortic rupture, and growth depression. Expand
Preliminary investigation of the relationship between bovine congenital lathyrism induced by aminoacetonitrile and the lupine induced crooked calf disease.
TLDR
Maternal feeding of the lathyrogen aminoacetonitrile, the range plant Lupinus caudatus, and an extract of this plant - expected to contain lathyrogens if present in the plant - all produced clinically similar congenital defects in calves, suggesting a possible relationship between lathyrism and lupine-induced crooked calf disease. Expand
Osteolathyrogenic effects on the developing rat foetus.
  • V. Ferm
  • Biology, Medicine
  • Journal of embryology and experimental morphology
  • 1960
TLDR
The present study was devised to determine the effect of a known osteolathyrogenic agent during specific stages of gestation and especially to observe theeffect of this agent during the early critical stages of embryogenesis. Expand
An apparent relationship between locoism and lathyrism.
TLDR
It was demonstrated that the known lathyrogens, aminoacetonitrile and alpha, gamma-diaminobutyric acid, as well as an extract from the loco plant (expected to contain lathyrogen if present in the plant) produced many of the abortive, teratogenic and neurologic effects and signs evident in animals in true locoism. Expand
Pathology of the Nervous System
Lathyrus Factor Activity of Beta-Aminopropionitrile and Related Compounds.∗
Summary β-amino propionitrile will produce all the changes which have been described in rats fed 50% Lathyrus odoratus pea meal. None of the supplements fed with BAPN inhibited the development of… Expand
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