Latex beads internalization and quantitative proteomics join forces to decipher the endosomal proteome.


The proteome analysis of endocytic compartments has been constrained by the limited purity of the organelle fractions obtained by current biochemical methods. Duclos and coworkers have developed a novel method to isolate highly purified endosomal organelles based on small latex beads internalization followed by gradient centrifugation and successfully… (More)
DOI: 10.1586/epr.11.27