Latest view on the mechanism of action of deep brain stimulation

  title={Latest view on the mechanism of action of deep brain stimulation},
  author={C. Hammond and R. Ammari and B. Bioulac and L. Garc{\'i}a},
  journal={Movement Disorders},
  • C. Hammond, R. Ammari, +1 author L. García
  • Published 2008
  • Psychology, Medicine
  • Movement Disorders
  • How does deep brain stimulation (DBS) applied at high frequency (100 Hz and above, HFS) in diverse points of cortico‐basal ganglia thalamo‐cortical loops alleviate symptoms of neurological disorders such as Parkinson's disease, dystonia, and obsessive compulsive disorders? Do the effects of HFS stem solely or even largely from local effects on the stimulated brain structure or are they also mediated by actions of HFS on distal structures? Indeed, HFS as an extracellular stimulation is expected… CONTINUE READING
    186 Citations
    Closing the loop of deep brain stimulation
    • 85
    • PDF
    Neurophysiology of deep brain stimulation.
    • 33
    Deep brain stimulation mechanisms: beyond the concept of local functional inhibition
    • 153
    Effects of antidromic and orthodromic activation of STN afferent axons during DBS in Parkinson's disease: a simulation study
    • 41
    • PDF
    Therapeutic Deep Brain Stimulation in Parkinsonian Rats Directly Influences Motor Cortex
    • 218
    • PDF
    Detection of single unit spikes during orthodromic-high frequency stimulation in rat hippocampus
    Selective GABA release as a mechanistic basis of high-frequency stimulation used for the treatment of neuropsychiatric diseases
    • 24
    • Highly Influenced


    Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition.
    • 662
    • PDF
    Mechanisms of action of deep brain stimulation (DBS)
    • 288
    Mechanisms of deep brain stimulation: an intracellular study in rat thalamus
    • 103
    • PDF
    Adenosine is crucial for deep brain stimulation–mediated attenuation of tremor
    • 221
    • PDF
    Dual Effect of High-Frequency Stimulation on Subthalamic Neuron Activity
    • 247
    • PDF
    Selective Attenuation of Afferent Synaptic Transmission as a Mechanism of Thalamic Deep Brain Stimulation-Induced Tremor Arrest
    • 99
    • PDF