Latest view on the mechanism of action of deep brain stimulation

@article{Hammond2008LatestVO,
  title={Latest view on the mechanism of action of deep brain stimulation},
  author={Constance Hammond and Rachida Ammari and Bernard H. Bioulac and Liliana Garcia},
  journal={Movement Disorders},
  year={2008},
  volume={23}
}
How does deep brain stimulation (DBS) applied at high frequency (100 Hz and above, HFS) in diverse points of cortico‐basal ganglia thalamo‐cortical loops alleviate symptoms of neurological disorders such as Parkinson's disease, dystonia, and obsessive compulsive disorders? Do the effects of HFS stem solely or even largely from local effects on the stimulated brain structure or are they also mediated by actions of HFS on distal structures? Indeed, HFS as an extracellular stimulation is expected… Expand
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