Latest advances in the discovery of fatty acid amide hydrolase inhibitors

@article{Bisogno2013LatestAI,
  title={Latest advances in the discovery of fatty acid amide hydrolase inhibitors},
  author={T. Bisogno and M. Maccarrone},
  journal={Expert Opinion on Drug Discovery},
  year={2013},
  volume={8},
  pages={509 - 522}
}
Introduction: Fatty acid amide hydrolase (FAAH) is the major catabolic enzyme of the endocannabinoid N-arachidonoylethanolamine (anandamide) that, with different degrees of efficiency, also hydrolyzes other endogenous fatty acid ethanolamides. FAAH is increasingly being considered a relevant therapeutic target, especially in models of inflammatory pain. The opportunity to selectively increase the endocannabinoid tone only in those tissues where such an enhancement can be beneficial might result… Expand
48 Citations
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents.
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