Latest Advances in Understanding Preeclampsia

@article{Redman2005LatestAI,
  title={Latest Advances in Understanding Preeclampsia},
  author={Christopher W. G. Redman and Ian L. Sargent},
  journal={Science},
  year={2005},
  volume={308},
  pages={1592 - 1594}
}
Preeclampsia is a relatively common pregnancy disorder that originates in the placenta and causes variable maternal and fetal problems. In the worst cases, it may threaten the survival of both mother and baby. We summarize recent work on the causes of preeclampsia, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition. The circulating factors derived from the placenta, which contributes to the clinical syndrome, are now better understood. This brief… Expand
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TLDR
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TLDR
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TLDR
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TLDR
Although the placenta plays a crucial role in the development of preeclampsia, the onset, severity, and progression is significantly affected by the maternal response to placentally derived factors and proteins. Expand
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TLDR
Emerging data on the pathogenesis of preeclampsia are discussed and therapeutic options are reviewed and it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeClampsia. Expand
Preeclampsia and angiogenic imbalance.
TLDR
New discoveries in the molecular pathogenesis of preeclampsia suggest a key role for altered expression of placental antiangiogenic factors and the role of angiogenic proteins in early placental vascular development is just beginning to be explored. Expand
The biology of preeclampsia.
TLDR
A discussion of several possible mechanisms and putative theories proposed for preeclampsia, with particular emphasis on the recent discovery of a new genetic mouse model offering new opportunities to explore experimental therapies. Expand
Angiogenic Factors in Preeclampsia: From Diagnosis to Therapy.
TLDR
The renal biopsy and autopsy studies from preeclamptic patients showed renal glomerular endotheliosis, a unique form of microvascular endothelial injury that is described as the classic lesion of this disorder. Expand
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TLDR
The current evidence for the role of abnormal placentation and therole of placental factors such as the antiangiogenic factor, sFLT1 (soluble fms-like tyrosine kinase 1) in the pathogenesis of the maternal syndrome of preeclampsia is discussed. Expand
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References

SHOWING 1-10 OF 18 REFERENCES
Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications.
TLDR
A critical review of the epidemiologic and pathologic literature supports the hypothesis that preeclampsia is the result of heterogeneous causes, and the implications of this hypothesis are discussed, particularly its impact on the development of rules to predict the occurrence of preeClampsia. Expand
Hypoxia and sFlt-1 in preeclampsia: the "chicken-and-egg" question.
TLDR
New evidence is provided that effects of hypoxia are cell type specific and that in placental cytotrophoblasts, hypoxIA induces an excess production of sFlt-1, which leads to VEGF deficiency and, consequently, an antiangiogenic state. Expand
Pre-eclampsia, the placenta and the maternal systemic inflammatory response--a review.
TLDR
Evidence is presented that apoptotic or necrotic debris shed from the syncytial surface of the placenta constitutes the inflammatory stimulus in all pregnancies, which explains many features of pre-eclampsia including its occurrence with either larger placentae or small oxidatively stressed placente. Expand
Pre-eclampsia and the placenta
TLDR
The earlier theories for the causation of pre-eclampsia assumed that deportation was the cause of eclamptic fits, but later evidence that it is a feature of normal human pregnancy has nullified this supposition. Expand
Placental Oxidative Stress: From Miscarriage to Preeclampsia
TLDR
Miscarriage, missed miscarriage, and early- and late-onset preeclampsia represent a spectrum of disorders secondary to deficient trophoblast invasion, and high levels of oxidative stress in the periphery may induce formation of the chorion laeve. Expand
Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?
TLDR
Evidence is increasingly linking the maternal vascular, metabolic, and inflammatory complications of pregnancy with an increased risk of vascular disease in later life (table), and this article summarises the evidence, notes important areas for further research, and discusses potential practical implications. Expand
Contemporary concepts of the pathogenesis and management of preeclampsia.
TLDR
The main-stay of therapy for preeclampsia re-mainsclinicalrecognition through pre-natal care and termination of treatment with delivery with delivery, which leads to recognition throughpre-natalcare andtermination of treatment as well as prophylactic seizure therapy. Expand
Oxidative stress and preeclampsia: rationale for antioxidant clinical trials.
TLDR
A combination of vitamins C and E is a promising prophylactic strategy for prevention of preeclampsia and a combination test involving several relevant biomarkers is likely to provide the best predictive potential. Expand
Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia
TLDR
It is concluded that elevated levels of NKB in early pregnancy may be an indicator of hypertension and pre-eclampsia, and that treatment with certain neurokinin receptor antagonists may be useful in alleviating the symptoms. Expand
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the condition has anExpand
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