Lateralized effects of diazepam on frontal brain electrical asymmetries in rhesus monkeys

  title={Lateralized effects of diazepam on frontal brain electrical asymmetries in rhesus monkeys},
  author={Richard J. Davidson and Ned H. Kalin and Steven E. Shelton},
  journal={Biological Psychiatry},

Lateralized response to diazepam predicts temperamental style in rhesus monkeys.

Animals showed greater relative left-sided frontal activation in response to diazepam compared with the preceding baseline, and the magnitude of this shift was strongly correlated with an aggregate measure of freezing time.

Functional regional asymmetry in intrahemisphere coherencein the EEG during conditioning in dogs

Comparison of averaged intrahemisphere EEG coherence values in the left and right hemispheres of the brain revealed individual features of regional interhemisphere relationships.

The Role of the Central Nucleus of the Amygdala in Mediating Fear and Anxiety in the Primate

Results suggest that similar to rodent species, the primate CeA plays a role in mediating fear- and anxiety-related behavioral and endocrine responses and patterns of asymmetric frontal brain electrical activity, as assessed by regional scalp EEG, did not significantly differ between control and lesioned monkeys.

Is Resting Anterior EEG Alpha Asymmetry a Trait Marker for Depression?

Increased variability of anterior EEG asymmetry may be a characteristic feature for depression, and, if so, this would challenge the notion that anterior EEG alpha asymmetry is a trait marker for depression.

Asymmetry in the dorsolateral prefrontal cortex and aggressive behavior: A continuous theta-burst magnetic stimulation study

Results indicate that using inhibitory continuous theta-burst magnetic stimulation to target the left DLPFC was associated with a greater increase in aggressive responses than right DLP FC stimulation, and it is concluded that D LPFC asymmetry is involved in modulating reactive and proactive aggression.

Regional brain metabolism during alcohol intoxication.

The results support similar though not identical mechanisms for the effects of alcohol and benzodiazepines on brain glucose metabolism, and the fact that lorazepam, but not alcohol, reduced thalamic metabolism, an effect associated with sleepiness, could explain the higher sedative effects of lorzepam than of alcohol.

Alprazolam-induced EEG spectral power changes in rhesus monkeys: a translational model for the evaluation of the behavioral effects of benzodiazepines.

Alprazolam induces dose- and topography-dependent EEG changes in rhesus monkeys and provides a valuable model for studying benzodiazepine pharmacology.



Asymmetrical brain electrical activity discriminates between psychometrically-matched verbal and spatial cognitive tasks.

Correlations between EEG and task performance indicated that CZ-referenced parietal alpha asymmetry accounted for the most variance in verbal task performance, indicating robust differences in asymmetrical brain physiology that are produced by well-matched verbal and spatial cognitive tasks.

Approach-withdrawal and cerebral asymmetry: emotional expression and brain physiology. I.

These findings illustrate the utility of using facial behavior to verify the presence of emotion, are consistent with the notion of emotion-specific physiological patterning, and underscore the importance of anterior cerebral asymmetries for emotions associated with approach and withdrawal.

EEG measures of cerebral asymmetry: conceptual and methodological issues.

  • R. Davidson
  • Psychology
    The International journal of neuroscience
  • 1988
Two conceptual issues which are central to studies of EEG asymmetries are introduced: the distinction between hemispheric specialization and activation, and the importance of rostral-caudal differences for the understanding of both specialization andactivation.

Individual differences in anterior brain asymmetry and fundamental dimensions of emotion.

Additional correlational analyses revealed robust relations between anterior asymmetry and PA and NA, particularly among subjects who demonstrated stable patterns of EEG activation over time, and was unrelated to individual differences in generalized reactivity.

Frontal brain asymmetry predicts infants' response to maternal separation.

Examined whether certain features of infant temperament might be related to individual differences in the asymmetry of resting frontal activation. EEG was recorded from the left and right frontal and

Ethanol effects on EEG spectra in monkeys: comparison to morphine and diazepam.

  • C. EhlersT. Reed
  • Physics
    Electroencephalography and clinical neurophysiology
  • 1987

Electrical Activity of the Brain

The present brief review is intended to cover the period between Sep­ tember 1938 and September 1940 with particular reference to studies not included in the previous review of Davis.

Psychometric properties of resting anterior EEG asymmetry: temporal stability and internal consistency.

Analyses including other frequency bands indicated that degree of stability varied somewhat as a function of band and region, and asymmetry was less stable than absolute power.