Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study.

@article{Gabbay2007LateralizedCM,
  title={Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study.},
  author={Vilma Gabbay and David A Hess and Songtao Liu and James S. Babb and Rachel G. Klein and Oded Gonen},
  journal={The American journal of psychiatry},
  year={2007},
  volume={164 12},
  pages={1881-9}
}
OBJECTIVE Proton magnetic resonance spectroscopy ((1)H-MRS) has been increasingly used to examine striatal neurochemistry in adult major depressive disorder. This study extends the use of this modality to pediatric major depression to test the hypothesis that adolescents with major depression have elevated concentrations of striatal choline and creatine and lower concentrations of N-acetylaspartate. METHOD Fourteen adolescents (ages 12-19 years, eight female) who had major depressive disorder… CONTINUE READING