Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid.

@article{Kim2007LateralSO,
  title={Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid.},
  author={K Kim and Dong-Hyun Kim and Hyun-Hee Jang and Mihee Kim and Dae-hwan Kim and Joon-Sik Kim and J Kim and Ho Zoon Chae and Taeho Ahn and Chul-Ho Yun},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={468 2},
  pages={226-33}
}
The lateral segregation of anionic phospholipids phosphatidic acid (PA), phosphatidylinositol (PI), and phosphatidylserine (PS) was detected after addition of cytochrome P450 2B1 (CYP2B1). The tendency of lipid clustering was highly dependent on the type of anionic phospholipids examined. PA was the most highly clustered while PI and PS clustered to a lesser degree. Moreover, liposomes containing anionic phospholipids form anionic phospholipid-rich microdomains in the presence of CYP2B1… CONTINUE READING

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