Lateral recognition of a dye hapten by a llama VHH domain.

@article{Spinelli2001LateralRO,
  title={Lateral recognition of a dye hapten by a llama VHH domain.},
  author={Silvia L Spinelli and Mariella Tegoni and Leon Gerardus Joseph Frenken and Cees van Vliet and Christian Cambillau},
  journal={Journal of molecular biology},
  year={2001},
  volume={311 1},
  pages={
          123-9
        }
}
Camelids, camels and llamas, have a unique immune system able to produce heavy-chain only antibodies. Their VH domains (VHHs) are the smallest binding units produced by immune systems, and therefore suitable for biotechnological applications through heterologous expression. The recognition of protein antigens by these VHHs is rather well documented, while less is known about the VHH/hapten interactions. The recently reported X-ray structure of a VHH in complex with a copper-containing azo-dye… CONTINUE READING
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