Lateral phosphorylation propagation: an aspect of feedback signalling?

  title={Lateral phosphorylation propagation: an aspect of feedback signalling?},
  author={Christian Tischer and Philippe I H Bastiaens},
  journal={Nature Reviews Molecular Cell Biology},
Local stimulation with epidermal growth factor can induce lateral propagation of epidermal-growth-factor-receptor phosphorylation at the plasma membrane. We discuss mechanisms of phosphorylation propagation and its possible function. Is it the spatial transmission of a local stimulus or is it an aspect of a feedback-signalling-reaction network that generates a switch response to growth-factor stimulation? 

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