Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium.

@article{Kucharzik2003LateralML,
  title={Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium.},
  author={Torsten Kucharzik and Andrew T. Gewirtz and Didier Merlin and James L. Madara and Ifor R Williams},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={284 4},
  pages={C888-96}
}
Lipoxin A(4) (LXA(4)) and its stable analogs downregulate chemokine secretion in polarized epithelia. This anti-inflammatory effect has been suggested to be mediated by the LXA(4) receptor (LXA(4)R), a G protein-coupled receptor. To determine whether LXA(4)R is expressed on the apical, basolateral, or both poles of intestinal epithelia, an NH(2)-terminal c-myc epitope tag was added to the human LXA(4)R cDNA and recombinant retroviruses were used to transduce polarized epithelial cells. In… CONTINUE READING