Lateral habenula as a source of negative reward signals in dopamine neurons

@article{Matsumoto2007LateralHA,
  title={Lateral habenula as a source of negative reward signals in dopamine neurons},
  author={Masayuki Matsumoto and Okihide Hikosaka},
  journal={Nature},
  year={2007},
  volume={447},
  pages={1111-1115}
}
Midbrain dopamine neurons are key components of the brain’s reward system, which is thought to guide reward-seeking behaviours. Although recent studies have shown how dopamine neurons respond to rewards and sensory stimuli predicting reward, it is unclear which parts of the brain provide dopamine neurons with signals necessary for these actions. Here we show that the primate lateral habenula, part of the structure called the epithalamus, is a major candidate for a source of negative reward… CONTINUE READING
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