Lateral dimerization of the E-cadherin extracellular domain is necessary but not sufficient for adhesive activity.

@article{Ozawa2002LateralDO,
  title={Lateral dimerization of the E-cadherin extracellular domain is necessary but not sufficient for adhesive activity.},
  author={Masayuki Ozawa},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 22},
  pages={
          19600-8
        }
}
Cadherins are transmembrane glycoproteins involved in Ca(2+)-dependent cell-cell adhesion. Using L cells coexpressing E-cadherin constructs with different epitope tags, we examined the lateral dimerization of E-cadherin and its adhesive activity by co-immunoprecipitation and aggregation assays, respectively. Although the transmembrane domain is required for dimerization, tail-less constructs possessing the transmembrane domain of either N-cadherin or CD45 show dimerization and are active in… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

Similar Papers

Loading similar papers…