Lateral Signaling Mediated by Axon Contact and Calcium Entry Regulates Asymmetric Odorant Receptor Expression in C. elegans

@article{Troemel1999LateralSM,
  title={Lateral Signaling Mediated by Axon Contact and Calcium Entry Regulates Asymmetric Odorant Receptor Expression in C. elegans},
  author={Emily R Troemel and Alvaro Sagasti and Cornelia I Bargmann},
  journal={Cell},
  year={1999},
  volume={99},
  pages={387-398}
}
C. elegans detects several odorants with the bilaterally symmetric pair of AWC olfactory neurons. A stochastic, coordinated decision ensures that the candidate odorant receptor gene str-2 is expressed in only one AWC neuron in each animal--either the left or the right neuron, but never both. An interaction between the two AWC neurons generates asymmetric str-2 expression in a process that requires normal axon guidance and probably AWC axon contact. This interaction induces str-2 expression by… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.
119 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 119 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

A novel family of divergent seventransmemexpression in a single AWC is off

  • C. M. Coburn, C. I. Bargmann
  • 1999

AWC on a side that failed to fill with DiI. None of these animals expressed str-2::GFP on the contralateral

  • P. J. Clyne, C. G. Warr, M. R. Freeman, D. Lessing, J. Kim
  • was still visible,
  • 1999
1 Excerpt

Ca21 channel cause myotonia in Caenorhabditis elegans

  • D.Z.J. Weinshenker, A. Wei, L. Salkoff, J. H. Thomas
  • 1999

Combinatorial The structure of the nervous system of the nematode Caenorhabditis receptor codes for odors

  • J. G. White, E. Southgate, +5 authors L. B. Buck
  • Cell
  • 1999

Occasionally, the ablation appeared to damage but not kill

  • preL.V, R. Paulsen, S. G. Britt
  • 1999

Regulation of a behavioral clock, muscle excitation, and a genetically defined target by the C

  • D. J. Reiner, E. M. Newton, H. Tian, J. H. Thomas
  • elegans unc-43 CaM Kinase II. Nature, in press.
  • 1999
2 Excerpts

Similar Papers

Loading similar papers…