Lateral Drug Diffusion in Human Nails

@article{Palliyil2014LateralDD,
  title={Lateral Drug Diffusion in Human Nails},
  author={Biji B. Palliyil and Cong Li and Suzan Owaisat and David B. Lebo},
  journal={AAPS PharmSciTech},
  year={2014},
  volume={15},
  pages={1429-1438}
}
The main objective of the current work is to demonstrate the process of passive lateral diffusion in the human nail plate and its effect on the passive transungual permeation of antifungal drug ciclopirox olamine (CPO). A water soluble dye, methyl red sodium salt (MR) was used to visualize the process of lateral diffusion using a novel suspended nail experiment. The decline in concentration of CPO correlates with that of concentration of MR from the proximal to the distal end of the nail in… CONTINUE READING
BETA

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Photothermal imaging in 3D surface analysis of membrane drug delivery.

  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2010
VIEW 1 EXCERPT