Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action.

@article{Saharinen1999LatentTG,
  title={Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action.},
  author={Juha Saharinen and Marko Hyyti{\"a}inen and Jussi Taipale and Jorma Keski-Oja},
  journal={Cytokine & growth factor reviews},
  year={1999},
  volume={10 2},
  pages={99-117}
}
Growth factors of the transforming growth factor-beta family are potent regulators of the extracellular matrix formation, in addition to their immunomodulatory and regulatory roles for cell growth. TGF-beta s are secreted from cells as latent complexes containing TGF-beta and its propeptide, LAP (latency-associated peptide). In most cells LAP is covalently linked to an additional protein, latent TGF-beta binding protein (LTBP), forming the large latent complex. LTBPs are required for efficient… CONTINUE READING
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