Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

@article{Isogai2003LatentTG,
  title={Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.},
  author={Zenzo Isogai and Robert N. Ono and Shin Ushiro and Douglas R. Keene and Yan Chen and Roberta Mazzieri and Noe L. Charbonneau and Dieter P Reinhardt and Daniel B. Rifkin and Lynn Y. Sakai},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 4},
  pages={2750-7}
}
Latent transforming growth factor beta-binding protein 1 (LTBP-1) targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Fibrillins are extracellular matrix macromolecules whose primary function is architectural: fibrillins assemble into ultrastructurally distinct microfibrils that are ubiquitous in the connective tissue space. LTBPs and fibrillins are highly homologous… CONTINUE READING
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