Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation.

@article{Ewan2002LatentTG,
  title={Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation.},
  author={Kenneth BR Ewan and G. Shyamala and Shraddha A. Ravani and Yang Tang and Rosemary J Akhurst and Lalage Wakefield and Mary Helen Barcellos-Hoff},
  journal={The American journal of pathology},
  year={2002},
  volume={160 6},
  pages={
          2081-93
        }
}
Transforming growth factor-beta1 (TGF-beta 1) is a pluripotent cytokine that can inhibit epithelial proliferation and induce apoptosis, but is also widely implicated in breast cancer progression. Understanding its biological action in mammary development is critical for understanding its role in cancer. TGF-beta 1 is produced as a latent complex that requires extracellular activation before receptor binding. To better understand the spatial and temporal regulation of its action during mammary… CONTINUE READING

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