Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells.

@article{Najjar2005LatentMP,
  title={Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells.},
  author={Imen Najjar and Fanny Baran-Marszak and Christophe Le Clorennec and Christelle Laguillier and Olivier Schischmanoff and Ibtissam Youlyouz-Marfak and Martin Schlee and Georg W. Bornkamm and Martine Rapha{\"e}l and Jean Feuillard and R{\'e}mi Fagard},
  journal={Journal of virology},
  year={2005},
  volume={79 8},
  pages={4936-43}
}
Constitutive activation of signal transducer and activator of transcription 1 (STAT1) is a distinctive feature of Epstein-Barr virus (EBV)-immortalized B cells (lymphoblastoid cell lines [LCLs]). The expression of STAT1 in these cells is modulated by the latent membrane protein 1 (LMP1), but the mechanism of STAT1 activation has remained unclear. We demonstrate that the tyrosine phosphorylation of STAT1 in LCLs results from an indirect pathway encompassing an NF-kappaB-dependent secretion of… CONTINUE READING