Latent inhibition: the nucleus accumbens connection revisited

  title={Latent inhibition: the nucleus accumbens connection revisited},
  author={Jeffrey A. Gray and Paula M. Moran and Grigory A. Grigoryan and Scott L. Peters and Andrew M. J. Young and Michael H. Joseph},
  journal={Behavioural Brain Research},

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing

Results suggest that the abolition ofLI produced by NAc shell lesions is not readily reproduced by regionally restricted DA depletion within NAc; core rather than shell NAc mediates amphetamine-induced abolition of LI; overshadowing is modulated by different neural substrates.

The Effects of a Serotoninergic Substrate of the Nucleus Accumbens on Latent Inhibition

  • L. Loskutova
  • Psychology, Biology
    Neuroscience and Behavioral Physiology
  • 2004
The importance of serotoninergic terminals in the nucleus accumbens for latent inhibition is discussed, along with the mechanism of their interaction with the dopaminergic system during the formation of this effect.

Dopamine D1 receptor involvement in latent inhibition and overshadowing

The data indicate that, while LI may be unaffected by selective manipulation of activity at D1 receptors, the effects of amphetamine on LI are to some extent dependent on actions at D 1 receptors.

Systemic or intra-accumbens injection of D-amphetamine delays habituation to a tone stimulus in rats

D-Amphetamine delayed tone habituation data are consistent with electrophysiological and neurochemical data demonstrating the role of nucleus accumbens dopamine in novelty processing, and the relevance of the data to latent inhibition is discussed.

Disruption of Long-Term Depression Potentiates Latent Inhibition: Key Role for Central Nucleus of the Amygdala

A previously unknown role for central amygdala LTD in LI is revealed as a key mediator of cognitive flexibility required to respond to previously irrelevant stimuli that acquire significance through reinforcement.



Haloperidol potentiation of latent inhibition in rats: evidence for a critical role at conditioning rather than pre-exposure.

It is demonstrated that haloperidol given before conditioning only is equally as effective as haloperodol given twice, before pre-exposure and conditioning, in potentiating LI after 10 pre-Exposures, pointing to conditioning as the critical time for the action of dopaminergic manipulations on LI.

Calcium dependence of sensitised dopamine release in rat nucleus accumbens following amphetamine challenge: implications for the disruption of latent inhibition

It is shown here that a single pretreatment with amphetamine is sufficient to sensitise the locomotor response to amphetamine challenge 24 h later, consistent with the concept that It is the calcium, and hence impulse, dependence of increased accumbal DA release, rather than its magnitude, which is critical for the disruption of LI.

Differential effects of microinjections of d-amphetamine into the nucleus accumbens or the caudate putamen on the rat's ability to ignore an irrelevant stimulus.

The results are discussed in terms of the role of the mesolimbic dopamine system in learning to ignore an irrelevant stimulus and the use of LI as a possible animal model of the attentional deficit that seems to characterize some subpopulations of schizophrenic humans.

Neural substrates of latent inhibition: the switching model.

  • I. Weiner
  • Psychology, Biology
    Psychological bulletin
  • 1990
It is proposed that the preexposed stimulus loses its capacity to affect behavior in conditioning, even though it predicts reinforcement, because the hippocampus inhibits the switching mechanism of the nucleus accumbens via the subiculum-accumbens pathway.

Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.

Results suggest that stimulation of nicotine receptors can either amplify or curtail the efficacy of mechanisms involved in filtering irrelevant stimuli from further cognitive processing and that the direction of this modulation depends on the CS preexposure parameters.

Both Electrolytic and Excitotoxic Lesions of Nucleus Accumbens Disrupt Latent Inhibition of Learning in Rats

The proposition that an intact nucleus accumbens is necessary for the normal development of latent inhibition of learning is supported.