Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

@article{Finzi1999LatentIO,
  title={Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy},
  author={Diana Finzi and Joel Blankson and Janet D Siliciano and Joseph B. Margolick and Karen Chadwick and Theodore Pierson and Kendall A. Smith and Julianna Lisziewicz and Franco Lori and Charles Flexner and Thomas C Quinn and Richard E. Chaisson and Eric J Rosenberg and Bruce M. Walker and Stephen Gange and Joel E. Gallant and Robert F. Siliciano},
  journal={Nature Medicine},
  year={1999},
  volume={5},
  pages={512-517}
}
Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in a latent form in resting CD4+ T cells. We measured the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable. The mean half-life of the latent reservoir was very long (43.9 months). If the latent reservoir consists of only 1 × 105 cells, eradication could take as… CONTINUE READING
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