Latent expression of p53 mutations and radiation-induced mammary cancer.

@article{Selvanayagam1995LatentEO,
  title={Latent expression of p53 mutations and radiation-induced mammary cancer.},
  author={C S Selvanayagam and Charles L. Davis and Michael Cornforth and Robert L. Ullrich},
  journal={Cancer research},
  year={1995},
  volume={55 15},
  pages={3310-7}
}
EF42 is a clonally derived preneoplastic cell lineage from irradiated mouse mammary tissue, which becomes neoplastic with time in vitro or in vivo. We now report that multiple mutations in p53 occur before the acquisition of the neoplastic phenotype. The selective expansion of mutant cells is accompanied by loss of heterozygosity at the p53 locus and c-myc… CONTINUE READING