Latent cytomegalovirus infection exacerbates experimental colitis.

@article{Onyeagocha2009LatentCI,
  title={Latent cytomegalovirus infection exacerbates experimental colitis.},
  author={Chukwuma Onyeagocha and Mohammad Sohrab Hossain and Amrita Kumar and Rheinallt M Jones and John D. Roback and Andrew T. Gewirtz},
  journal={The American journal of pathology},
  year={2009},
  volume={175 5},
  pages={
          2034-42
        }
}
Inflammatory bowel disease (IBD) severity is positively correlated with cytomegalovirus (CMV) infection. This may reflect CMV triggering and/or exacerbating flares of IBD and/or IBD or immunosuppressive drugs administered to patients with IBD increasing susceptibility to CMV infection. Herein, we performed studies in mice to investigate these possibilities. Mice administered murine CMV (MCMV) developed signs of acute viral infection (malaise and weight loss) and had MCMV loads that were readily… CONTINUE READING

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