Latent bone metastasis in breast cancer tied to Src-dependent survival signals.

@article{Zhang2009LatentBM,
  title={Latent bone metastasis in breast cancer tied to Src-dependent survival signals.},
  author={Xiang H. F. Zhang and Qiongqing Wang and William Gerald and Clifford A. Hudis and Larry Norton and Marcel Smid and John A. Foekens and Joan Massagu{\'e}},
  journal={Cancer cell},
  year={2009},
  volume={16 1},
  pages={67-78}
}
Metastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We report that a gene expression signature of Src activation is associated with late-onset bone metastasis in breast cancer. This link is independent of hormone receptor status or breast cancer subtype. In breast cancer cells, Src is dispensable for homing to the bones or lungs but is critical for the survival and outgrowth of these cells in the bone… CONTINUE READING
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