Latent and active p53 are identical in conformation

  title={Latent and active p53 are identical in conformation},
  author={Ayeda Ayed and Frans A. A. Mulder and Gwan-Su Yi and Ying Lu and Lewis E. Kay and Cheryl H. Arrowsmith},
  journal={Nature Structural Biology},
p53 is a nuclear phosphoprotein that regulates cellular fate after genotoxic stress through its role as a transcriptional regulator of genes involved in cell cycle control and apoptosis. The C-terminal region of p53 is known to negatively regulate sequence specific DNA-binding of p53; modifications to the C-terminus relieve this inhibition. Two models have been proposed to explain this latency: (i) an allosteric model in which the C-terminal domain interacts with another domain of p53 or (ii) a… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
71 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 71 extracted citations

Similar Papers

Loading similar papers…