Latent and active p53 are identical in conformation

@article{Ayed2001LatentAA,
  title={Latent and active p53 are identical in conformation},
  author={Ayeda Ayed and Frans A. A. Mulder and Gwan-Su Yi and Ying Lu and Lewis E. Kay and Cheryl H. Arrowsmith},
  journal={Nature Structural Biology},
  year={2001},
  volume={8},
  pages={756-760}
}
p53 is a nuclear phosphoprotein that regulates cellular fate after genotoxic stress through its role as a transcriptional regulator of genes involved in cell cycle control and apoptosis. The C-terminal region of p53 is known to negatively regulate sequence specific DNA-binding of p53; modifications to the C-terminus relieve this inhibition. Two models have been proposed to explain this latency: (i) an allosteric model in which the C-terminal domain interacts with another domain of p53 or (ii) a… CONTINUE READING
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