Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.

@article{Chen2002LatentTB,
  title={Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.},
  author={Yan Yu Chen and Branka Brukner Dabovi{\'c} and Justin P Annes and Daniel B. Rifkin},
  journal={FEBS letters},
  year={2002},
  volume={517 1-3},
  pages={
          277-80
        }
}
Latent transforming growth factor-beta (TGF-beta) binding protein (LTBP)-1, which is easily secreted, has been shown to enhance the secretion of TGF-beta. Here we show that another member of the LTBP family, LTBP-3, is not secreted by several cell types, but secretion occurs after coexpression with TGF-beta. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-beta propeptide. 

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Similar Papers

Loading similar papers…