Latent Regulatory Potential of Human-Specific Repetitive Elements

@inproceedings{Ward2013LatentRP,
  title={Latent Regulatory Potential of Human-Specific Repetitive Elements},
  author={Michelle C Ward and Michael D. Wilson and Nuno L. Barbosa-Morais and Dominic Schmidt and Rory Stark and Qun Pan and Petra C. Schwalie and Suraj Menon and Margus Lukk and Stephen Watt and David Thybert and Claudia Kutter and Kristina Kirschner and Paul Flicek and Benjamin J. Blencowe and Duncan T. Odom},
  booktitle={Molecular cell},
  year={2013}
}
At least half of the human genome is derived from repetitive elements, which are often lineage specific and silenced by a variety of genetic and epigenetic mechanisms. Using a transchromosomic mouse strain that transmits an almost complete single copy of human chromosome 21 via the female germline, we show that a heterologous regulatory environment can transcriptionally activate transposon-derived human regulatory regions. In the mouse nucleus, hundreds of locations on human chromosome 21 newly… CONTINUE READING
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