Latency to rapid eye movement sleep as a predictor of treatment response to fluoxetine and placebo in nonpsychotic depressed outpatients.

@article{Heiligenstein1994LatencyTR,
  title={Latency to rapid eye movement sleep as a predictor of treatment response to fluoxetine and placebo in nonpsychotic depressed outpatients.},
  author={John H. Heiligenstein and Douglas E. Faries and A. John Rush and John Sahl Andersen and Atul C. Pande and Howard P. Roffwarg and David L. Dunner and J. Christian Gillin and Steven P. James and H H Lahmeyer},
  journal={Psychiatry research},
  year={1994},
  volume={52 3},
  pages={
          327-39
        }
}
Fluoxetine and placebo were compared in 89 outpatients with major depression with (n = 45) or without (n = 44) a reduced or shortened rapid eye movement latency (SREML) (< or = 65 minutes) to determine whether rapid eye movement latency (REML) predicted placebo and/or antidepressant response. Men and women were stratified based on polysomnographic recordings and then randomly assigned to receive double-blind fluoxetine (20 mg/day) or placebo for 8 weeks after a 2-week, single-blind, placebo… CONTINUE READING

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