Latency and reactivation of human cytomegalovirus.

  title={Latency and reactivation of human cytomegalovirus.},
  author={John H. Sinclair and Patrick J G Sissons},
  journal={The Journal of general virology},
  volume={87 Pt 7},
Human cytomegalovirus (HCMV) persists as a subclinical, lifelong infection in the normal human host, maintained at least in part by its carriage in the absence of detectable infectious virus--the hallmark of latent infection. Reactivation from latency in immunocompromised individuals, in contrast, often results in serious disease. Latency and reactivation are defining characteristics of the herpesviruses and key to understanding their biology. However, the precise cellular sites in which HCMV… CONTINUE READING
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