Latency and reactivation of a thymidine kinase-negative bovine herpesvirus 1 deletion mutant

@article{Whetstone1992LatencyAR,
  title={Latency and reactivation of a thymidine kinase-negative bovine herpesvirus 1 deletion mutant},
  author={Cecelia A. Whetstone and Janice M. Miller and Bruce S. Seal and Leonard J. Bello and William J. Lawrence},
  journal={Archives of Virology},
  year={1992},
  volume={122},
  pages={207-214}
}
A bovine herpesvirus 1 (BHV 1) mutant variant with a deletion in the thymidine kinase (TK) gene was assessed for its ability to establish latency and be reactivated in cattle. After treatment with dexamethasone, reactivated TK− BHV 1 was isolated from one of four cattle that received virus by intravenous inoculation only, and from four of four cattle that received virus by intranasal, intravaginal, and intravenous inoculation. Results prove that TK− BHV 1 will establish latency and can be… CONTINUE READING

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Latency and reactivation of a thymidine kinase negative vaccine strain of pseudorabies virus in pigs

  • WL Mengeling, KM Lager
  • Arch Virol (in press)
  • 1991
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