Latency and reactivation of a thymidine kinase-negative bovine herpesvirus 1 deletion mutant

@article{Whetstone2005LatencyAR,
  title={Latency and reactivation of a thymidine kinase-negative bovine herpesvirus 1 deletion mutant},
  author={C. Whetstone and J. M. Miller and B. Seal and L. Bello and W. Lawrence},
  journal={Archives of Virology},
  year={2005},
  volume={122},
  pages={207-214}
}
  • C. Whetstone, J. M. Miller, +2 authors W. Lawrence
  • Published 2005
  • Biology, Medicine
  • Archives of Virology
  • SummaryA bovine herpesvirus 1 (BHV 1) mutant variant with a deletion in the thymidine kinase (TK) gene was assessed for its ability to establish latency and be reactivated in cattle. After treatment with dexamethasone, reactivated TK− BHV 1 was isolated from one of four cattle that received virus by intravenous inoculation only, and from four of four cattle that received virus by intranasal, intravaginal, and intravenous inoculation. Results prove that TK− BHV 1 will establish latency and can… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis.
    • 322
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 24 REFERENCES
    The role of herpes simplex virus type 1 thymidine kinase in pathogenesis.
    • 210
    • Open Access
    Determination of ability of a thymidine kinase-negative deletion mutant of bovine herpesvirus-1 to cause abortion in cattle.
    • 38
    Map location of the thymidine kinase gene of bovine herpesvirus 1.
    • 29
    • Open Access
    The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
    • 298
    • Open Access
    Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus.
    • 55
    • Open Access