Latency and persistence of respiratory syncytial virus despite T cell immunity.

  title={Latency and persistence of respiratory syncytial virus despite T cell immunity.},
  author={Jurgen Schwarze and Diarmund R O'Donnell and Angela Rohwedder and Peter J M Openshaw},
  journal={American journal of respiratory and critical care medicine},
  volume={169 7},
Respiratory syncytial virus (RSV) causes bronchiolitis in infants, which is associated with recurrent wheezing in later childhood. There is mounting evidence that the virus becomes latent or persists in vivo, but little is known about the mechanisms of its latency, persistence, and immune evasion. We therefore infected BALB/c mice intranasally with human RSV, analyzed sequential tissue samples by direct culture and polymerase chain reaction for viral and messenger RNA, and monitored antiviral… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 56 extracted citations

Viral acute lower respiratory infections impair CD8+ T cells through PD-1.

The Journal of clinical investigation • 2012
View 16 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…