Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection

@inproceedings{Krishna2017LatencyAssociatedEO,
  title={Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection},
  author={Benjamin A. Krishna and Emma L. Poole and Sarah E Jackson and Martine J. Smit and Mark R Wills and John H. Sinclair},
  booktitle={mBio},
  year={2017}
}
Reactivation of human cytomegalovirus (HCMV) latent infection from early myeloid lineage cells constitutes a threat to immunocompromised or immune-suppressed individuals. Consequently, understanding the control of latency and reactivation to allow targeting and killing of latently infected cells could have far-reaching clinical benefits. US28 is one of the few viral genes that is expressed during latency and encodes a cell surface G protein-coupled receptor (GPCR), which, during lytic infection… CONTINUE READING
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Latency and reactivation of human cytomegalovirus.

The Journal of infection • 2002
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