Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers.

@article{Reeves2005LatencyCR,
  title={Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers.},
  author={Matthew B Reeves and Paul A MacAry and Paul J Lehner and J. G. Sissons and John H. Sinclair},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 11},
  pages={4140-5}
}
Human cytomegalovirus (HCMV) persists as a subclinical, lifelong infection in the normal human host, but reactivation from latency in immunocompromised subjects results in serious disease. Latency and reactivation are defining characteristics of the herpesviruses and are key to understanding their biology; however, the precise cellular sites in which HCMV is carried and the mechanisms regulating its latency and reactivation during natural infection remain poorly understood. Here we present… CONTINUE READING