Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model.

@article{Falanga1991LateTW,
  title={Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model.},
  author={P B Falanga and Eugene C. Butcher},
  journal={European journal of immunology},
  year={1991},
  volume={21 9},
  pages={
          2259-63
        }
}
CBA/Ca mice injected with Plasmodium berghei develop cerebral malaria (CM) characterized by ataxia and progressive paralysis leading to death 7-9 days after experimental infection. The development of cerebral symptoms is a function of the immune response in susceptible strains, and depends on cell-cell interactions involving T helper cells and mononuclear phagocytes. Here we ask whether antibodies to cell adhesion receptors of the immune system can influence the development of CM in this mouse… CONTINUE READING

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