Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma.

@article{Benk1993LateRB,
  title={Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma.},
  author={Veronique M A Benk and Judy A. Adams and William U. Shipley and Marcia M Urie and Penelope Louise McManus and Jimmy T Efird and Chris G Willett and Michael Goitein},
  journal={International journal of radiation oncology, biology, physics},
  year={1993},
  volume={26 3},
  pages={551-7}
}
PURPOSE Dose escalation for prostate cancer by external beam irradiation is feasible by a 160 MeV perineal proton beam that reduces the volume of rectum irradiated. We correlated the total doses received to portions of the anterior rectum to study the possible relationship of the volume irradiated to the incidence of late rectal toxicity. METHODS We have randomized 191 patients with stages T3 and T4 prostatic carcinoma to one of two treatment dose arms. These were: 1) 75.6 Cobalt-Gy… CONTINUE READING

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