Late phase of the endoplasmic reticulum stress response pathway is regulated by Hog1 MAP kinase.


When unfolded proteins accumulate in the endoplasmic reticulum (ER) causing ER stress, the unfolded protein response (UPR) responds rapidly to induce a transcriptional program that functions to alleviate the stress. However, under extreme conditions, when UPR activation is not sufficient to alleviate ER stress, the stress may persist long term. Very little… (More)
DOI: 10.1074/jbc.M109.084681


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