Late onset hepatic failure: Clinical, serological and histological features

  title={Late onset hepatic failure: Clinical, serological and histological features},
  author={Alexander E. S. Gimson and John G O'grady and Roland J Ede and Bernard C. Portmann and Roger Williams},
The clinical, laboratory and histological features of 47 patients with what is defined as late onset hepatic failure are reviewed. Twenty‐five of the patients werefemale and 22 male with a median age of 45 years. Hepatic dysfunction was severe as evidenced by the prolongation of prothrombin time (median = 32 sec, range = 17 to 120 sec). In only four cases was a viral etiology proven (2 hepatitis B, 2 hepatitis A) although the similarity of the clinical features to patients with fulminant viral… 
Subacute hepatic failure
Subacute hepatic failure is a clinical entity distinct from acute liver failure, due to fulminant hepatitis, and from chronic liver failure, due to chronic active hepatitis. Viral hepatitis is the
Fulminant Hepatitis in Children: Evidence for an Unidentified Hepatitis Virus
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Hyperacute liver failure acute Liver Failure-current Management Strategies
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It is indicated that fulminant hepatic failure can be predicted, by a simple discrimination equation, at the stage of severe acute hepatitis.
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[Fulminant hepatitis B].
The prognosis for survival without transplantation in fulminant hepatitis is limited by the measures of medical treatment and new specific therapeutic modalities which must be developed through basic research.


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The pattern of hepatic necrosis characterized by intralobular and interlobular bridging of portal triads or central veins, when found during the acute phase of viral hepatitis, indicates a severe form of the disease that may lead to fatal hepatic failure or the development of cirrhosis in a significant number of patients.
Clinical and prognostic differences in fulminant hepatitis type A, B and non-A non-B.
In 73 patients with fulminant viral hepatitis, non-A non-B hepatitis (NANB) was most common and the survival rate was higher in the HAV group (43.4%) compared with the HBV group (16.6%) and NANB group (9.3%) (p less than 0.005).
Acute hepatic necrosis and fulminant hepatic failure.
This definition excludes the hepatic encephalopathy of hepatic cirrhosis and of chronic hepatitis, which produces a slightly different clinical picture, but fulminant hepatic failure as defined here may of course occur as a superimposed phenomenon in patients with these conditions.
Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure.
A controlled trial of 44 patients was undertaken to evaluate the use of dexamethasone (32 mg stat, 8 mg qds) in preventing, and intravenous mannitol (1 g/kg) in reversing the cerebral oedema of
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Hepatitis type A, B, and non-A non-B in fulminant hepatitis.
Serological investigations were carried out in 22 patients with fulminant hepatitis admitted to Medical Department A, Rigshospitalet, Copenhagen, in 1970-77 and the survival rate was not statistically different for patients having type A, B, or non-A non-B hepatitis.
Current results with orthotopic liver grafting in Cambridge/King's College Hospital series.
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