Late-onset depression with mild cognitive deficits: electrophysiological evidences for a preclinical dementia syndrome.

Abstract

Mild cognitive impairment (MCI) is present in up to 60% of patients with late-onset depression and constitutes a major diagnostic problem in geriatric psychiatry. Searching for sensitive markers for the detection of early brain changes suggestive of dementia, we compared this depressive risk population with mildly to moderately demented patients and cognitively unimpaired depressed patients using EEG power and coherence. We found a considerable similarity between Alzheimer's disease patients and cognitively impaired depressed patients regarding the cognitive profile and EEG pattern. Changes in EEG power and coherence at frontotemporal leads in depressive patients with MCI thereby allowed discrimination from cognitively unimpaired patients with a sensitivity of 88% and a specifity of 81%.

Cite this paper

@article{Brassen2004LateonsetDW, title={Late-onset depression with mild cognitive deficits: electrophysiological evidences for a preclinical dementia syndrome.}, author={Stefanie Brassen and Dieter F. Braus and Wolfgang Weber-Fahr and Heike Tost and Steffen Moritz and Georg Adler}, journal={Dementia and geriatric cognitive disorders}, year={2004}, volume={18 3-4}, pages={271-7} }