Late-onset and Recurrent Neonatal Group B Streptococcal Disease Associated with Breast-milk Transmission

@article{Kotiw2003LateonsetAR,
  title={Late-onset and Recurrent Neonatal Group B Streptococcal Disease Associated with Breast-milk Transmission 
},
  author={Michael Kotiw and G W Zhang and Grant Daggard and Elizabeth Reiss-Levy and John W. Tapsall and Andrew H. Numa},
  journal={Pediatric and Developmental Pathology},
  year={2003},
  volume={6},
  pages={251-256}
}
The purpose of the study was to determine the epidemiological relationships in three unrelated cases of neonatal late-onset Group B streptococcal (GBS) disease and maternal breast-milk infection with GBS. All deliveries were by cesarean section; case 1 was at term, and cases 2 and 3 were at 32- and 33-wk gestation, respectively. Case 1 relates to a mother with clinical mastitis and recurrent GBS infection in a 20-day-old male infant. Following antibiotic therapy and cessation of breastfeeding… 
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References

SHOWING 1-10 OF 18 REFERENCES
GROUP B STREPTOCOCCAL BREAST ABSCESS IN A MOTHER AND MASTITIS IN HER INFANT
TLDR
It is likely that the pathogenesis of infection in this mother-infant pair was circular, and that either early abscess formation during the mother's first clinical infection and/or milk stasis due to decreased frequency of breast-feeding resulted in transient group B streptococcal bacteremia, with seeding of breast tissue in the newborn.
Perinatal mortality in Victoria, Australia: role of group B Streptococcus.
Clonal analysis of Streptococcus agalactiae isolated from infants with neonatal sepsis or meningitis and their mothers and from healthy pregnant women.
TLDR
Evaluated group B streptococci isolated from infants with neonatal sepsis or meningitis and their mothers differ from GBS isolated from healthy pregnant women who gave birth to healthy infants, finding a population structure like that of traditional pathogens.
Analysis of DNA restriction fragment length polymorphism extends the evidence for breast milk transmission in Streptococcus agalactiae late-onset neonatal infection.
TLDR
Analysis of restriction fragment length polymorphism of total DNA and of ribosomal DNA (ribotyping) was used to document four cases of Streptococcus agalactiae mother-to-infant transmission potentially associated with ingestion of infected mother's milk, extending the evidence for breast milk transmission in S. agalACTiae late-onset neonatal infection.
Restriction endonuclease analysis of group B streptococcal isolates from two distinct geographical regions.
Sudden Increase in Isolation of Group B Streptococci, Serotype V, Is Not Due to Emergence of a New Pulsed-Field Gel Electrophoresis Type
TLDR
The majority of isolates of group B streptococcus, serotype V (GBS-V), are of one PFGE subtype and that this subtype was predominate before the increase in disease caused by G BS-V and that GBS- V disease is caused by several different subtypes.
Identification of a high-virulence clone of type III Streptococcus agalactiae (group B Streptococcus) causing invasive neonatal disease.
TLDR
Chromosomal genotypes of 128 isolates of six serotypes of Streptococcus agalactiae recovered predominantly from human infants in the United States were characterized by an analysis of electrophoretically demonstrable allelic profiles at 11 metabolic enzyme loci.
Characterization of Streptococcus agalactiae strains by randomly amplified polymorphic DNA analysis
TLDR
This investigation identified 71 RAPD types and the three families of strains defined by multilocus enzyme electrophoresis analysis, which contain most of the cerebrospinal fluid isolates, were also identified by clustering analysis of RAPD data.
A RAPD‐PCR genotyping assay which correlates with serotypes of group B streptococci
TLDR
The RAPD‐PCR assay is faster, more convenient and easier to perform than alternative DNA analytical procedures such as Pulsfield Gel Electrophoresis and suggests that the assay may be robust enough for use in routine epidemiological investigations.
Genomic diversity among Streptococcus agalactiae isolates detected by a degenerate oligonucleotide-primed amplification assay.
TLDR
A random-amplified polymorphic DNA assay using partially degenerate oligonucleotides as primers was used for the characterization of 78 epidemiologically related and unrelated clinical isolates of Streptococcus agalactiae belonging to different serotypes, uncovering the extent of genomic heterogeneity existent within serotypes.
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