Late manifestation of subclinical hyperthyroidism after goitrogenesis in an index patient with a N670S TSH receptor germline mutation masquerading as TSH receptor antibody negative Graves' disease.

@article{Schaarschmidt2012LateMO,
  title={Late manifestation of subclinical hyperthyroidism after goitrogenesis in an index patient with a N670S TSH receptor germline mutation masquerading as TSH receptor antibody negative Graves' disease.},
  author={Joerg Schaarschmidt and Scott Paschke and Mesude {\"O}zerden and Holger Jaeschke and Sandra Ekman von Huth and M. Eszlinger and Jarek Meller and Ralf Paschke},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2012},
  volume={44 13},
  pages={
          962-5
        }
}
In 27 families with familial non-autoimmune hyperthyroidism (FNAH) reported up to date, the onset of hyperthyroidism varies from 18 months to 60 years. Also the manifestation of goitres is variable in these families. A 74-year-old woman first presented at the age of 69 years with tachyarrhythmia and hypertension. After initial treatment of her hypertension and oral anticoagulation for her intermittent atrial fibrillation, a thyroid workup revealed a suppressed TSH and normal fT3 and fT4. TPO… CONTINUE READING
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References

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N670S TSHR Germline Mutation .

J Schaarschmidt
  • Horm Metab Res
  • 2012

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