Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease.

@article{Churg2012LateIW,
  title={Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease.},
  author={Andrew Churg and C. Marshall and Don D. Sin and Sarah J Bolton and Steven Zhou and Katherine R. Thain and Elaine B. Cadogan and Justine Maltby and Matthew G. Soars and Philip R. Mallinder and Joanne L. Wright},
  journal={American journal of respiratory and critical care medicine},
  year={2012},
  volume={185 1},
  pages={34-43}
}
RATIONALE Inflammation and oxidative stress are linked to the deleterious effects of cigarette smoke in producing chronic obstructive pulmonary disease (COPD). Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but also drives inflammatory reactions and tissue oxidation. OBJECTIVES To determine the role of MPO in COPD. METHODS We treated guinea pigs with a 2-thioxanthine MPO inhibitor, AZ1, in a 6-month cigarette smoke exposure model, with one… CONTINUE READING
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