Late histological and functional changes in the P23H rat retina after photoreceptor loss

@article{Kolomiets2010LateHA,
  title={Late histological and functional changes in the P23H rat retina after photoreceptor loss},
  author={Bogdan Kolomiets and {\'E}lisabeth Dubus and Manuel Simonutti and Serge Georges Rosolen and Serge Picaud},
  journal={Neurobiology of Disease},
  year={2010},
  volume={38},
  pages={47-58}
}
Several strategies have been proposed to restore useful vision following photoreceptor degeneration. However, a very few studies have investigated late anatomical changes and functional state of residual retinal neurons after complete photoreceptor loss. We investigated the progressive degeneration of retinal ganglion cells (RGCs) in P23H rats. The RGC multielectrode array recordings indicated lower firing rates, disappearance of broad-scale, and maintenance of short-scale pairwise correlations… CONTINUE READING

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47–58 recordings inmice

  • B. Kolomiets
  • Neurobiology of Disease
  • 2010

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