Late-gestation ventricular myocardial reduction in fetuses of hyperglycemic CD1 mice is associated with increased apoptosis.

@article{Gutierrez2009LategestationVM,
  title={Late-gestation ventricular myocardial reduction in fetuses of hyperglycemic CD1 mice is associated with increased apoptosis.},
  author={J Claudio Gutierrez and Mary Renee Prater and Bonnie J. Smith and Larry E Freeman and Murali K. Mallela and Steven David Holladay},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2009},
  volume={86 5},
  pages={409-15}
}
BACKGROUND Previous work in our laboratory showed reduced myocardium and dilated ventricular chambers in gestation day (GD) 17 hearts that were collected from hyperglycemic CD1 mouse dams. Pre-breeding maternal immune stimulation, using Freund's complete adjuvant (FCA), diminished the severity of these fetal heart lesions. The following experiments were performed to detect possible changes in fetal heart apoptotic cell death, under hyperglycemic conditions and with or without maternal immune… CONTINUE READING