Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory

@article{Ou2010LateEO,
  title={Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory},
  author={Li-Chin Ou and Shiu-Hwa Yeh and Po-Wu Gean},
  journal={Neurobiology of Learning and Memory},
  year={2010},
  volume={93},
  pages={372-382}
}
In many instances, increase in neuronal activity can induce biphasic secretion of a modulator. The initial release of the modulator triggers the induction of synaptic plasticity, whereas the second-phase release reinforces the efficacy of synaptic transmission and growth of dendrites and axons. In this study, we showed that fear conditioning not only induced the first but also a second peak of brain-derived neurotrophic factor (BDNF) expression. Fluorescent immunohistostaining confirmed that… CONTINUE READING

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