Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

@article{Goulder1997LateEF,
  title={Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS},
  author={Philip J. R. Goulder and Rodney E. Phillips and Robert A. Colbert and Stephen McAdam and Graham Ogg and Martin A. Nowak and P L F Giangrande and G. A. Luzzi and Barbara Morgana and Anne Edwards and Andrew J McMichael and Sarah Rowland-Jones},
  journal={Nature Medicine},
  year={1997},
  volume={3},
  pages={212-217}
}
The precise role played by HIV-specific cytotoxic T lymphocytes (CTL) in HIV infection remains controversial. Despite strong CTL responses being generated during the asymptomatic phase, the virus persists and AIDS ultimately develops. It has been argued that the virus is so variable, and the virus turnover so great that escape from CTL recognition would occur continually, but so far there is limited evidence for CTL escape. The opposing argument is that evidence for CTL escape is present but… CONTINUE READING
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