Late endosomes derive from early endosomes by maturation

@article{Stoorvogel1991LateED,
  title={Late endosomes derive from early endosomes by maturation},
  author={W. Stoorvogel and G. Strous and H. Geuze and V. Oorschot and Alan L. Schwartzt},
  journal={Cell},
  year={1991},
  volume={65},
  pages={417-427}
}
Endocytosed proteins destined for degradation in lysosomes are targeted mainly to early endosomes following uptake. Late endosomes are the major site for entry of newly synthesized lysosomal hydrolases via the cation-independent mannose 6-phosphate receptor into the degradative pathway. No consensus exists as to the mechanism of transport from early to late endosomes. We used asialoorosomucoid and transferrin to label selected parts of the degradative and receptor-recycling pathways… Expand
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  • 2000
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