Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney.

@article{Lind1997LateDS,
  title={Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney.},
  author={Robert Cornelis Lind and A. Jay Gandolfi},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={142 1},
  pages={201-7}
}
Dimethyl sulfoxide (DMSO) can protect the liver from injury produced by a variety of hepatotoxicants when administered prior to or concomitant with the toxicants. This protective action has previously been attributed to DMSO-induced inhibition of bioactivation of the compounds to toxic intermediates. In these studies, the ability of DMSO to provide protection when administered 10 hr after a toxicant was evaluated in several animal models of xenobiotic-induced liver and kidney injury. In the… CONTINUE READING

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