Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity.

@article{Boeckh2003LateCD,
  title={Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity.},
  author={Michael Boeckh and Wendy W Leisenring and Stanley R Riddell and Raleigh A. Bowden and Meei-li Huang and David H Myerson and Terry L Stevens-Ayers and Mary E D Flowers and Terri Cunningham and Lawrence Corey},
  journal={Blood},
  year={2003},
  volume={101 2},
  pages={407-14}
}
Ganciclovir effectively prevents cytomegalovirus (CMV) disease in the first 100 days after allogeneic hematopoietic stem cell transplantation (HSCT), but late-onset CMV disease is increasingly observed. We designed a prospective cohort study to define the incidence and risk factors for late CMV infection in patients who undergo HSCT. CMV-seropositive patients were studied prospectively for CMV infection (quantitative pp65 antigenemia, quantitative CMV-DNA, blood culture), T-cell immunity (CMV… CONTINUE READING
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